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The elusive role of the SPRY2 domain in RyR1

Tae, HanShen; Wei, L; Willemse, Hermia; Mirza, Shamaruh; Gallant, Esther; Board, Philip; Dirksen, Robert; Casarotto, Marco; Dulhunty, Angela


The second of three SPRY domains (SPRY2, S1085 -V1208) located in the skeletal muscle ryanodine receptor (RyR1) is contained within regions of RyR1 that influence EC coupling and bind to imperatoxin A, a toxin probe of RyR1 channel gating. We examined the binding of the F loop (P1107-A1121) in SPRY2 to the ASI/basic region in RyR1 (T3471-G3500, containing both alternatively spliced (ASI) residues and neighboring basic amino acids). We then investigated the possible influence of this interaction...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Channels
DOI: 10.4161/chan.5.2.14407


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