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Fluorescent target array T helper assay: A multiplex flow cytometry assay to measure antigen-specific CD4+ T cell-mediated B cell help in vivo

Quah, Ben; Wijesundara, Danushka; Ranasinghe, Charani; Parish, Christopher


CD4+ T cells play a central role in regulating the immune response. Their effector function is commonly assessed by their capacity to secrete cytokines detected by ELISPOT and intracellular cytokine staining. However, one aspect of their effector function that is often overlooked is their ability to help activation of cognate B cells directly, a process that is initiated through the engagement of their T cell-receptor (TCR) with cognate peptide presented on major histocompatibility complex...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Journal of Immunological Methods
DOI: 10.1016/j.jim.2012.10.013


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