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Cationised radiolabelled nanoparticles for perfusion imaging of the lungs

Lobov, Sergey; King, David; Knox, Karen; Senden, Timothy; Stephens, Ross

Description

Diagnostic imaging of the blood perfusion of the lungs is currently performed using particles of macro-aggregated albumin, which are mechanically arrested at limiting diameters of the capillary bed. While the proportion of blood flow obstructed is typically very low and temporary, it would seem more desirable to image lung perfusion in patients using a non-obstructive method, and using materials that avoid biological hazards. We have characterised the in vitro and in vivo properties of a...[Show more]

dc.contributor.authorLobov, Sergey
dc.contributor.authorKing, David
dc.contributor.authorKnox, Karen
dc.contributor.authorSenden, Timothy
dc.contributor.authorStephens, Ross
dc.date.accessioned2015-12-10T23:35:06Z
dc.identifier.issn0142-9612
dc.identifier.urihttp://hdl.handle.net/1885/69711
dc.description.abstractDiagnostic imaging of the blood perfusion of the lungs is currently performed using particles of macro-aggregated albumin, which are mechanically arrested at limiting diameters of the capillary bed. While the proportion of blood flow obstructed is typically very low and temporary, it would seem more desirable to image lung perfusion in patients using a non-obstructive method, and using materials that avoid biological hazards. We have characterised the in vitro and in vivo properties of a colloid of a cationised radiolabelled nanocomposite. The nanoparticles comprise a Technetium-99m core encapsulated in graphitic carbon, and coated with low molecular weight poly-lysine to provide a strong charge-based affinity for the endothelial glycocalyx of the lung. Following intravenous injection in rabbits and cats, the nanoparticles rapidly distribute and localise in the lungs, thus enabling gamma camera imaging of lung perfusion. Repeat administration of this colloid in both species over several weeks indicates favourable biocompatibility.
dc.publisherPergamon-Elsevier Ltd
dc.sourceBiomaterials
dc.subjectKeywords: Biological hazard; Blood flow; Blood perfusion; Diagnostic imaging; Gamma cameras; Graphitic carbons; In-vitro; Intravenous injections; Low molecular weight; Lung perfusion; Macro-aggregated albumins; Perfusion imaging; Polycations; Polylysine; Technetium Diagnostic imaging; Lung perfusion; Polycations; Radiolabelled nanocomposite
dc.titleCationised radiolabelled nanoparticles for perfusion imaging of the lungs
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume34
dc.date.issued2013
local.identifier.absfor110203 - Respiratory Diseases
local.identifier.absfor110313 - Nuclear Medicine
local.identifier.ariespublicationf5625xPUB2100
local.type.statusPublished Version
local.contributor.affiliationLobov, Sergey, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationKing, David, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationKnox, Karen, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationSenden, Timothy , College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationStephens, Ross, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue6
local.bibliographicCitation.startpage1732
local.bibliographicCitation.lastpage1738
local.identifier.doi10.1016/j.biomaterials.2012.11.022
dc.date.updated2016-02-24T08:54:09Z
local.identifier.scopusID2-s2.0-84870847527
local.identifier.thomsonID000315002400009
CollectionsANU Research Publications

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