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Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation

Sarcevic, Boris; Mawson, Amanda; Baker, Rohan; Sutherland, Robert L

Description

Cell cycle progression in eukaryotes is mediated by phosphorylation of protein substrates by the cyclin-dependent kinases (CDKs). We screened a cDNA library by solid-phase phosphorylation and isolated hHR6A as a CDK2 substrate. hHR6A is the human homologue of the product of the Saccharomyces cerevisiae RAD6/UBC2 gene, a member of the family of ubiquitin-conjugating enzymes. hHR6A is phosphorylated in vitro by CDK-1 and -2 on Ser120, a residue conserved in all hHR6A homologues, resulting in a...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/69598
Source: EMBO Journal, The
DOI: 10.1093/emboj/21.8.2009

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