Longordo, Fabio; Jing, Fan; Thierry, Steimer; Kopp, Caroline; Luthi, Anita
Study Objectives: "Gentle handling" has become a method of choice for 4-6 h sleep deprivation in mice, with repeated brief handling applied before sleep deprivation to induce habituation. To verify whether mice do indeed habituate, we assess how 6 days of repeated brief handling impact on resting behavior, on stress, and on the subunit content of N-methyl-D-aspartate receptors (NMDARs) at hippocampal synapses, which is altered by sleep loss. We discuss whether repeated handling biases the...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.