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Do mice habituate to "gentle handling"? A comparison of resting behavior, corticosterone levels and synaptic function in handled and undisturbed C57BL/6J mice

Longordo, Fabio; Jing, Fan; Thierry, Steimer; Kopp, Caroline; Luthi, Anita


Study Objectives: "Gentle handling" has become a method of choice for 4-6 h sleep deprivation in mice, with repeated brief handling applied before sleep deprivation to induce habituation. To verify whether mice do indeed habituate, we assess how 6 days of repeated brief handling impact on resting behavior, on stress, and on the subunit content of N-methyl-D-aspartate receptors (NMDARs) at hippocampal synapses, which is altered by sleep loss. We discuss whether repeated handling biases the...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Sleep


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