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Atomic force microscopy imaging of DNA-cationic liposome complexes optimised for gene transfection into neuronal cells

Wangerek, Louise; Dahl, Hans-Hendrik; Senden, Timothy; Carlin, John; Dunstan, David Edwin; Ioannou, Panayiotis; Williamson, Robert; Forrest, S


Background: Cationic liposomes represent an important gene delivery system due to their low immunogenicity, but are relatively inefficient, with optimisation of DNA-liposome complexes (lipoplexes) for transfection necessary for each cell type of interest. There have been few studies examining optimisation in neuronal cell types or determining how the structure of lipoplexes affects transfection efficiency. Methods: Four commercially available cationic liposome formulations were used to optimise...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Gene Medicine
DOI: 10.1002/1521-2254(200101/02)3:1<72::AID-JGM157>3.0.CO;2-M


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