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Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage

MacKay, Michael; Lobachevsky, Pavel N.; Vasireddy, RS; Broadhurst, Sam; Sprung, Carl N.; Karagiannis, Tom C; Smith, Andrea; Radford, Ian R; Martin, Roger F


Purpose: The therapeutic ratio for ionising radiation treatment of tumour is a trade-off between normal tissue side-effects and tumour control. Application of a radioprotector to normal tissue can reduce side-effects. Here we study the effects of a new radioprotector on the cellular response to radiation. Methylproamine is a DNA-binding radioprotector which, on the basis of published pulse radiolysis studies, acts by repair of transient radiation-induced oxidative species on DNA. To...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: International Journal of Radiation Biology
DOI: 10.3109/09553002.2011.530333


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