Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage
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MacKay, Michael; Lobachevsky, Pavel N.; Vasireddy, RS; Broadhurst, Sam; Sprung, Carl N.; Karagiannis, Tom C; Smith, Andrea; Radford, Ian R; Martin, Roger F
Description
Purpose: The therapeutic ratio for ionising radiation treatment of tumour is a trade-off between normal tissue side-effects and tumour control. Application of a radioprotector to normal tissue can reduce side-effects. Here we study the effects of a new radioprotector on the cellular response to radiation. Methylproamine is a DNA-binding radioprotector which, on the basis of published pulse radiolysis studies, acts by repair of transient radiation-induced oxidative species on DNA. To...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/69482 |
Source: | International Journal of Radiation Biology |
DOI: | 10.3109/09553002.2011.530333 |
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File | Description | Size | Format | Image |
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01_MacKay_Protection_by_methylproamine_2011.pdf | 302.54 kB | Adobe PDF | Request a copy | |
02_MacKay_Protection_by_methylproamine_2011.pdf | 1.79 MB | Adobe PDF | Request a copy |
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