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Contraction anisocoria: Segregation, summation, and saturation in the pupillary pathway

Carle, Corinne; Maddess, Ted; James, Andrew

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PURPOSE. To investigate the neural basis of contraction anisocoria and any implications for assessments using pupillary responses, through analysis of topographic variation in amplitudes of direct and consensual pupil responses. METHODS. Direct and consensual pupillary contraction amplitudes were analyzed from six studies in which 120 normal subjects were tested with 24 different stimulus variants. The dichoptically presented multifocal stimulus arrays subtended ± 30° of visual field but varied...[Show more]

dc.contributor.authorCarle, Corinne
dc.contributor.authorMaddess, Ted
dc.contributor.authorJames, Andrew
dc.date.accessioned2015-12-10T23:34:21Z
dc.identifier.issn1552-5783
dc.identifier.urihttp://hdl.handle.net/1885/69406
dc.description.abstractPURPOSE. To investigate the neural basis of contraction anisocoria and any implications for assessments using pupillary responses, through analysis of topographic variation in amplitudes of direct and consensual pupil responses. METHODS. Direct and consensual pupillary contraction amplitudes were analyzed from six studies in which 120 normal subjects were tested with 24 different stimulus variants. The dichoptically presented multifocal stimulus arrays subtended ± 30° of visual field but varied in color (achromatic or yellow), number of test regions (24 to 60/eye), mean regional presentation interval (0.25 to 16 s), and pulse time-course (33 to 150 ms, flickered or steady). The 290 cd/m2 test-regions were displayed on a 10 cd/m2 background. Ratios between mean direct and consensual responses were calculated for each region. Results were quantified using multivariate linear analysis. RESULTS. Direct responses within the temporal hemifield were significantly larger than consensual for all stimulus protocols. Across the 24 protocols these differences ranged between 13.8% (t1415 = 3.06, P < 0.01) and 27.0% (t990 = 5.72, P < 0.0001). Differences in the nasal field were mostly non-significant. Contraction amplitudes varied systematically across the visual field. By contrast, direct/consensual ratios were markedly uniform within each hemifield. CONCLUSIONS. The distribution of signal from the pretectal olivary nuclei to each Edinger-Westphal nucleus differs depending on the hemifield being stimulated. A simple model incorporating segregation and summation of afferent signals, and differing saturation of midbrain pathways is proposed. This appears to explain inconsistent observations in the literature and predicates the need for separate assessment of direct and consensual responses at hemifield or better resolution.
dc.publisherAssociation for Research in Vision and Opthalmology
dc.rightsAuthor/s retain copyright
dc.sourceInvestigative Ophthalmology and Visual Science
dc.subjectKeywords: adult; article; color; contraction anisocoria; Edinger Westphal nucleus; female; human; human experiment; male; mesencephalon; multivariate analysis; normal human; olivary nucleus; pretectum; priority journal; pupil; pupillography; signal transduction; vi
dc.titleContraction anisocoria: Segregation, summation, and saturation in the pupillary pathway
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume52
dc.date.issued2011
local.identifier.absfor111301 - Ophthalmology
local.identifier.ariespublicationf2965xPUB2014
local.type.statusPublished Version
local.contributor.affiliationCarle, Corinne, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMaddess, Ted, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationJames, Andrew, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.issue5
local.bibliographicCitation.startpage2365
local.bibliographicCitation.lastpage2371
local.identifier.doi10.1167/iovs.10-6335
local.identifier.absseo920107 - Hearing, Vision, Speech and Their Disorders
local.identifier.absseo920203 - Diagnostic Methods
dc.date.updated2016-02-24T08:21:08Z
local.identifier.scopusID2-s2.0-79956035235
local.identifier.thomsonID000289411300003
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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