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Tic22 is an essential chaperone required for protein import into the apicoplast

Glaser, Stephanie; van Dooren, Giel; Agrawal, Swati; Brooks, Carrie F; McFadden, Geoffrey I; Striepen, Boris; Higgins, Matthew K


Most plastids proteins are post-translationally imported into organelles through multisubunit translocons. The TIC and TOC complexes perform this role in the two membranes of the plant chloroplast and in the inner two membranes of the apicoplasts of the apicomplexan parasites, Toxoplasma gondii and Plasmodium falciparum. Tic22 is a ubiquitous intermembrane translocon component that interacts with translocating proteins. Here, we demonstrate that T. gondii Tic22 is an apicoplast-localized...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M112.405100
Access Rights: Open Access


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