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Education modulates the impact of white matter lesions on the risk of mild cognitive impairment and dementia

Mortamais, Marion; Portet, Florence; Brickman, Adam M; Provenzano, Frank A; Muraskin, Jordan; Akbaraly, Tasnime N.; Berr, Claudine; Touchon, Jacques; Bonafe, Alain; Le Bars, Emmanuelle; Menjot de Champfleur, Nicolas; Maller, Jerome J.; Meslin, Chantal; Sabatier, Robert; Ritchie, Karen; Artero, Sylvaine


Objectives Conflicting results have been reported regarding the association between white matter lesions (WML) and cognitive impairment. We hypothesized that education, a marker of cognitive reserve (CR), could modulate the effects of WML on the risk of mild cognitive impairment (MCI) or dementia. Methods We followed 500 healthy subjects from a cohort of community-dwelling persons aged 65 years and over (ESPRIT Project). At baseline, WML volume was measured using a semi-automatic method on...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: American Journal of Geriatric Psychiatry
DOI: 10.1016/j.jagp.2013.06.002


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