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Expression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer

Myklebust, MP; Li, Z; Tran, TH; Rui, H; Knudsen, Erik; Elsaleh, Hany; Fluge, Ø; Vonen, B; Myrvold, HE; Leh, S; Tveit, KM; Pestell, Richard; Dahl, Olav

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Background:The aim of this study was to investigate the value of the cyclin D1 isoforms D1a and D1b as prognostic factors and their relevance as predictors of response to adjuvant chemotherapy with 5-fluorouracil and levamisole (5-FU/LEV) in colorectal cancer (CRC).Methods:Protein expression of nuclear cyclin D1a and D1b was assessed by immunohistochemistry in 335 CRC patients treated with surgery alone or with adjuvant therapy using 5-FU/LEV. The prognostic and predictive value of these two...[Show more]

dc.contributor.authorMyklebust, MP
dc.contributor.authorLi, Z
dc.contributor.authorTran, TH
dc.contributor.authorRui, H
dc.contributor.authorKnudsen, Erik
dc.contributor.authorElsaleh, Hany
dc.contributor.authorFluge, Ø
dc.contributor.authorVonen, B
dc.contributor.authorMyrvold, HE
dc.contributor.authorLeh, S
dc.contributor.authorTveit, KM
dc.contributor.authorPestell, Richard
dc.contributor.authorDahl, Olav
dc.date.accessioned2015-12-10T23:33:20Z
dc.identifier.issn0007-0920
dc.identifier.urihttp://hdl.handle.net/1885/69243
dc.description.abstractBackground:The aim of this study was to investigate the value of the cyclin D1 isoforms D1a and D1b as prognostic factors and their relevance as predictors of response to adjuvant chemotherapy with 5-fluorouracil and levamisole (5-FU/LEV) in colorectal cancer (CRC).Methods:Protein expression of nuclear cyclin D1a and D1b was assessed by immunohistochemistry in 335 CRC patients treated with surgery alone or with adjuvant therapy using 5-FU/LEV. The prognostic and predictive value of these two molecular markers and clinicopathological factors were evaluated statistically in univariate and multivariate survival analyses.Results:Neither cyclin D1a nor D1b showed any prognostic value in CRC or colon cancer patients. However, high cyclin D1a predicted benefit from adjuvant therapy measured in 5-year relapse-free survival (RFS) and CRC-specific survival (CSS) compared to surgery alone in colon cancer (P0.012 and P0.038, respectively) and especially in colon cancer stage III patients (P0.005 and P0.019, respectively) in univariate analyses. An interaction between treatment group and cyclin D1a could be shown for RFS (P0.004) and CSS (P0.025) in multivariate analysis.Conclusion:Our study identifies high cyclin D1a protein expression as a positive predictive factor for the benefit of adjuvant 5-FU/LEV treatment in colon cancer, particularly in stage III colon cancer.
dc.publisherNature Publishing Group
dc.sourceBritish Journal of Cancer
dc.subjectKeywords: cyclin D1; cyclin d1a; cyclin d1b; fluorouracil; isoprotein; levamisole; unclassified drug; adult; advanced cancer; article; cancer chemotherapy; cancer prognosis; cancer specific survival; clinical assessment; colorectal cancer; controlled study; female; Colorectal cancer; Cyclin D1a; Cyclin D1b; IHC; Treatment response
dc.titleExpression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume107
dc.date.issued2012
local.identifier.absfor111200 - ONCOLOGY AND CARCINOGENESIS
local.identifier.ariespublicationf5625xPUB1966
local.type.statusPublished Version
local.contributor.affiliationMyklebust, MP, University of Bergen
local.contributor.affiliationLi, Z, Thomas Jefferson University
local.contributor.affiliationTran, TH, Thomas Jefferson University
local.contributor.affiliationRui, H, Thomas Jefferson University
local.contributor.affiliationKnudsen, Erik, Thomas Jefferson University
local.contributor.affiliationElsaleh, Hany, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationFluge, Ø, Haukeland University Hospital
local.contributor.affiliationVonen, B, University Hospital of North Norway
local.contributor.affiliationMyrvold, HE, Trondheim University Hospital
local.contributor.affiliationLeh, S, Haukeland University Hospital
local.contributor.affiliationTveit, KM, University of Oslo
local.contributor.affiliationPestell, Richard, Thomas Jefferson University
local.contributor.affiliationDahl, Olav, Haukeland University Hospital
local.description.embargo2037-12-31
local.bibliographicCitation.issue10
local.bibliographicCitation.startpage1684
local.bibliographicCitation.lastpage1691
local.identifier.doi10.1038/bjc.2012.463
dc.date.updated2016-02-24T08:52:13Z
local.identifier.scopusID2-s2.0-84869089879
local.identifier.thomsonID000300990200004
CollectionsANU Research Publications

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