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Expression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer

Myklebust, MP; Li, Z; Tran, TH; Rui, H; Knudsen, Erik; Elsaleh, Hany; Fluge, Ø; Vonen, B; Myrvold, HE; Leh, S; Tveit, KM; Pestell, Richard; Dahl, Olav


Background:The aim of this study was to investigate the value of the cyclin D1 isoforms D1a and D1b as prognostic factors and their relevance as predictors of response to adjuvant chemotherapy with 5-fluorouracil and levamisole (5-FU/LEV) in colorectal cancer (CRC).Methods:Protein expression of nuclear cyclin D1a and D1b was assessed by immunohistochemistry in 335 CRC patients treated with surgery alone or with adjuvant therapy using 5-FU/LEV. The prognostic and predictive value of these two...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: British Journal of Cancer
DOI: 10.1038/bjc.2012.463


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