Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics
Nekrasov, Maxim; Amrichova, Jane; Parker, Brian J; Soboleva, Tatiana; Jack, Cameron; Williams, Rohan; Huttley, Gavin Austin; Tremethick, David
Description
Although it has been clearly established that well-positioned histone H2A.Z-containing nucleosomes flank the nucleosome-depleted region (NDR) at the transcriptional start site (TSS) of active mammalian genes, how this chromatin-based information is transmitted through the cell cycle is unknown. We show here that in mouse trophoblast stem cells, the amount of histone H2A.Z at promoters decreased during S phase, coinciding with homotypic (H2A.Z-H2A.Z) nucleosomes flanking the TSS becoming...[Show more]
Collections | ANU Research Publications |
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Date published: | 2012 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/69232 |
Source: | Nature Structural and Molecular Biology |
DOI: | 10.1038/nsmb.2424 |
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01_Nekrasov_Histone_H2A.Z_inheritance_2012.pdf | 1.76 MB | Adobe PDF | Request a copy |
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