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Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics

Nekrasov, Maxim; Amrichova, Jane; Parker, Brian J; Soboleva, Tatiana; Jack, Cameron; Williams, Rohan; Huttley, Gavin Austin; Tremethick, David


Although it has been clearly established that well-positioned histone H2A.Z-containing nucleosomes flank the nucleosome-depleted region (NDR) at the transcriptional start site (TSS) of active mammalian genes, how this chromatin-based information is transmitted through the cell cycle is unknown. We show here that in mouse trophoblast stem cells, the amount of histone H2A.Z at promoters decreased during S phase, coinciding with homotypic (H2A.Z-H2A.Z) nucleosomes flanking the TSS becoming...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Nature Structural and Molecular Biology
DOI: 10.1038/nsmb.2424


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