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Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency

Morris, Kelly; Cao, Feihua (Lucy); Onagi, Hideki; Altamore, Timothy; Gamble, Allan; Easton, Christopher

Description

The interactions of nineteen peptide substrates and fifteen analogous peptidomimetic glycolate inhibitors with human peptidylglycine α-amidating monooxygenase (PAM) have been investigated. The substrates and inhibitors are the prohormones of calcitonin a

dc.contributor.authorMorris, Kelly
dc.contributor.authorCao, Feihua (Lucy)
dc.contributor.authorOnagi, Hideki
dc.contributor.authorAltamore, Timothy
dc.contributor.authorGamble, Allan
dc.contributor.authorEaston, Christopher
dc.date.accessioned2015-12-10T23:33:19Z
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/1885/69230
dc.description.abstractThe interactions of nineteen peptide substrates and fifteen analogous peptidomimetic glycolate inhibitors with human peptidylglycine α-amidating monooxygenase (PAM) have been investigated. The substrates and inhibitors are the prohormones of calcitonin a
dc.publisherPergamon-Elsevier Ltd
dc.sourceBioorganic and Medicinal Chemistry Letters
dc.subjectKeywords: alpha amidating enzyme; antineoplastic agent; calcitonin; enzyme inhibitor; glycolic acid; oxytocin; peptidomimetic glycolate inhibitor; peptidylglycine alpha amidating monooxygenase inhibitor; unclassified drug; amino acid sequence; antineoplastic activi Glycolate inhibitors; Human cancer; Peptide substrates; Peptidylglycine a-amidating monooxygenase; Prohormones
dc.titleProhormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume22
dc.date.issued2012
local.identifier.absfor030501 - Free Radical Chemistry
local.identifier.ariespublicationf5625xPUB1962
local.type.statusPublished Version
local.contributor.affiliationMorris, Kelly, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationCao, Feihua (Lucy), College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationOnagi, Hideki, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationAltamore, Timothy, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationGamble, Allan, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationEaston, Christopher, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue23
local.bibliographicCitation.startpage7015
local.bibliographicCitation.lastpage7018
local.identifier.doi10.1016/j.bmcl.2012.10.004
local.identifier.absseo860899 - Human Pharmaceutical Products not elsewhere classified
dc.date.updated2016-02-24T08:52:11Z
local.identifier.scopusID2-s2.0-84869080405
local.identifier.thomsonID000310583100003
CollectionsANU Research Publications

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