Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency
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Morris, Kelly; Cao, Feihua (Lucy); Onagi, Hideki; Altamore, Timothy; Gamble, Allan; Easton, Christopher
Description
The interactions of nineteen peptide substrates and fifteen analogous peptidomimetic glycolate inhibitors with human peptidylglycine α-amidating monooxygenase (PAM) have been investigated. The substrates and inhibitors are the prohormones of calcitonin a
dc.contributor.author | Morris, Kelly | |
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dc.contributor.author | Cao, Feihua (Lucy) | |
dc.contributor.author | Onagi, Hideki | |
dc.contributor.author | Altamore, Timothy | |
dc.contributor.author | Gamble, Allan | |
dc.contributor.author | Easton, Christopher | |
dc.date.accessioned | 2015-12-10T23:33:19Z | |
dc.identifier.issn | 0960-894X | |
dc.identifier.uri | http://hdl.handle.net/1885/69230 | |
dc.description.abstract | The interactions of nineteen peptide substrates and fifteen analogous peptidomimetic glycolate inhibitors with human peptidylglycine α-amidating monooxygenase (PAM) have been investigated. The substrates and inhibitors are the prohormones of calcitonin a | |
dc.publisher | Pergamon-Elsevier Ltd | |
dc.source | Bioorganic and Medicinal Chemistry Letters | |
dc.subject | Keywords: alpha amidating enzyme; antineoplastic agent; calcitonin; enzyme inhibitor; glycolic acid; oxytocin; peptidomimetic glycolate inhibitor; peptidylglycine alpha amidating monooxygenase inhibitor; unclassified drug; amino acid sequence; antineoplastic activi Glycolate inhibitors; Human cancer; Peptide substrates; Peptidylglycine a-amidating monooxygenase; Prohormones | |
dc.title | Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 22 | |
dc.date.issued | 2012 | |
local.identifier.absfor | 030501 - Free Radical Chemistry | |
local.identifier.ariespublication | f5625xPUB1962 | |
local.type.status | Published Version | |
local.contributor.affiliation | Morris, Kelly, College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Cao, Feihua (Lucy), College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Onagi, Hideki, College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Altamore, Timothy, College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Gamble, Allan, College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Easton, Christopher, College of Physical and Mathematical Sciences, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 23 | |
local.bibliographicCitation.startpage | 7015 | |
local.bibliographicCitation.lastpage | 7018 | |
local.identifier.doi | 10.1016/j.bmcl.2012.10.004 | |
local.identifier.absseo | 860899 - Human Pharmaceutical Products not elsewhere classified | |
dc.date.updated | 2016-02-24T08:52:11Z | |
local.identifier.scopusID | 2-s2.0-84869080405 | |
local.identifier.thomsonID | 000310583100003 | |
Collections | ANU Research Publications |
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