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Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency

Morris, Kelly; Cao, Feihua (Lucy); Onagi, Hideki; Altamore, Timothy; Gamble, Allan; Easton, Christopher


The interactions of nineteen peptide substrates and fifteen analogous peptidomimetic glycolate inhibitors with human peptidylglycine α-amidating monooxygenase (PAM) have been investigated. The substrates and inhibitors are the prohormones of calcitonin a

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Bioorganic and Medicinal Chemistry Letters
DOI: 10.1016/j.bmcl.2012.10.004


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