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Redesigning the designer drug ecstasy:Non-psychoactive MDMA analogues exhibiting Burkitt's lymphoma cytotoxicity

Gandy, Michael N; McIldowie, Matthew; Lewis, Katie; Wasik, Agata M; Salomonczyk, Danielle; Wagg, Keith; Millar, Zak A; Tindiglia, David; Huot, Philippe; Johnston, Tom; Thiele, Sherri; Brotchie, Jonathan M


Burkitt's lymphoma (BL) is a particularly aggressive cancer that primarily affects African children. Unfortunately, effective and affordable treatment is out of reach of most of the afflicted. The illicit psychoactive drug methylenedioxymethamphetamine (MDMA, 'ecstasy') is cytotoxic to BL cell lines, but its low potency, psychoactivity and neurotoxicity preclude consideration as a therapeutic drug candidate. This paper describes the discovery of novel α-aryl analogues of MDMA that lack...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: MedChemComm
DOI: 10.1039/c0md00108b


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