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Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responses

Vogalis, Fivos; T, Shiraki; Kojima, D; Wada, Y; Nishiwaki, Y; Jarvinen, Jaakko; Sugiyama, J; Kawakami, K; Masai, I; Kawamura, S; Fukada, Y; Lamb, Trevor


To investigate the roles of G-protein receptor kinases (GRKs) in the light responses of vertebrate photoreceptors, we generated transgenic zebrafish lines, the rods of which express either cone GRK (GRK7) or rod GRK (GRK1) in addition to the endogenous GRK1, and we then measured the electrophysiological characteristics of single-cell responses and the behavioural responses of intact animals. Our study establishes the zebrafish expression system as a convenient platform for the investigation of...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Physiology
DOI: 10.1113/jphysiol.2010.204156


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