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A ZAP- 70 kinase domain variant prevents thymocyte-positive selection despite signalling CD 69 induction

Siggs, Owen; Yates (previously Loy), Adele; Schlenner, Susan; Liston, Adrian; Lesage, Sylvie; Goodnow, Christopher

Description

Summary: Quantitative reductions in T-cell receptor (TCR) signalling are associated with severe immunodeficiency, yet in certain cases can lead to autoimmunity. Mutation of the tyrosine kinase ZAP-70 can cause either of these outcomes, yet the limits of its signal transducing capacity are not well defined. To investigate these limits we have made use of mrtless: a chemically induced mutation of Zap70 associated with T-cell deficiency. Unlike cells devoid of ZAP-70, mrtless thymocytes showed...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/69010
Source: Immunology
DOI: 10.1111/imm.12220

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