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Ten years of leptin replacement therapy

Da Paz Filho, Gilberto; Wong, Ma-Li; Licinio, Julio

Description

Leptin is a pleiotropic cytokine-like hormone that is involved in the regulation of energy intake and expenditure, neuroendocrine function, immunity and lipid and glucose metabolism. The few humans with genetically based leptin deficiency provide a unique model to assess those effects. We have identified five Turkish patients (one male and two female adults; one boy and one girl) with congenital leptin deficiency due to a missense mutation in the leptin gene. Four of these patients were treated...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/69004
Source: Obesity Reviews
DOI: 10.1111/j.1467-789X.2010.00840.x

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