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Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of beta interferon coexpression on vaccine properties

Frese, Michael; Lee, Eva; Larena, Maximilian; Lim, Pek Siew; Rao, Sudha; Matthaei, Klaus; Khromykh, Alexander A; Ramshaw, Ian; Lobigs, Mario


Infectious clone technologies allow the rational design of live attenuated viral vaccines with the possibility of vaccine-driven coexpression of immunomodulatory molecules for additional vaccine safety and efficacy. The latter could lead to novel strategies for vaccine protection against infectious diseases where traditional approaches have failed. Here we show for the flavivirus Murray Valley encephalitis virus (MVEV) that incorporation of the internal ribosome entry site (IRES) of...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.03051-13
Access Rights: Open Access


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