Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of beta interferon coexpression on vaccine properties
Infectious clone technologies allow the rational design of live attenuated viral vaccines with the possibility of vaccine-driven coexpression of immunomodulatory molecules for additional vaccine safety and efficacy. The latter could lead to novel strategies for vaccine protection against infectious diseases where traditional approaches have failed. Here we show for the flavivirus Murray Valley encephalitis virus (MVEV) that incorporation of the internal ribosome entry site (IRES) of...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Virology|
|Access Rights:||Open Access|
|01_Frese_Internal_ribosome_entry_2014.pdf||4.09 MB||Adobe PDF|
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