Skip navigation
Skip navigation

Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT

Lehane, Adele; Van Schalkwyk, Donelly; Valderramos, Stephanie G; Fidock, David A; Kirk, Kiaran


Mutant forms of the Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediate chloroquine resistance by effluxing the drug from the parasite's digestive vacuole, the acidic organelle in which chloroquine exerts its parasiticidal effect. However, different parasites bearing the same mutant form of PfCRT can vary substantially in their chloroquine susceptibility. Here, we have investigated the biochemical basis for the difference in chloroquine response among transfectant parasite...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Antimicrobial Agents and Chemotherapy
DOI: 10.1128/AAC.01167-10
Access Rights: Open Access


File Description SizeFormat Image
01_Lehane_Differential_drug_efflux_or_2011.pdf1.13 MBAdobe PDF

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator