Prolonged Xenograft Survival Induced by Inducible Costimulator-Ig is Associated With Increased Forkhead Box P3+ Cells
Background: Blockade of the inducible costimulator (ICOS) pathway has been shown to prolong allograft survival; however, its utility in xenotransplantation is unknown. We hypothesize that local expression of ICOS-Ig by the xenograft will suppress the T-cell response resulting in significant prolonged graft survival. METHODS.: Pig iliac artery endothelial cells (PIEC) secreting ICOS-Ig were generated and examined for the following: (1) inhibition of allogeneic and xenogeneic proliferation of...[Show more]
|Collections||ANU Research Publications|
|01_Hodgson_Prolonged_Xenograft_Survival_2011.pdf||765.49 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.