Prolonged Xenograft Survival Induced by Inducible Costimulator-Ig is Associated With Increased Forkhead Box P3+ Cells
Hodgson, Russell; Christiansen, Dale; Ziolkowski, Andrew; Mouhtouris, Effie; Simeonovic, Charmaine; Ierino, Francesco; Sandrin, Mauro
Background: Blockade of the inducible costimulator (ICOS) pathway has been shown to prolong allograft survival; however, its utility in xenotransplantation is unknown. We hypothesize that local expression of ICOS-Ig by the xenograft will suppress the T-cell response resulting in significant prolonged graft survival. METHODS.: Pig iliac artery endothelial cells (PIEC) secreting ICOS-Ig were generated and examined for the following: (1) inhibition of allogeneic and xenogeneic proliferation of...[Show more]
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