Liang, B; Soka, M; Christensen, Alex Horby; Olesen, M; Larsen, Anders Peter; Knop, F K; Wang, Fan; Nielsen, J B; Andersen, M N; Humphreys, David T; Preiss, Thomas
The two-pore domain potassium channel, K2P3.1 (TASK-1) modulates background conductance in isolated human atrial cardiomyocytes and has been proposed as a potential drug target for atrial fibrillation (AF). TASK-1 knockout mice have a predominantly ventricular phenotype however, and effects of TASK-1 inactivation on atrial structure and function have yet to be demonstrated in vivo. The extent to which genetic variation in KCNK3, that encodes TASK-1, might be a determinant of susceptibility to...[Show more]
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