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Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis

Liang, B; Soka, M; Christensen, Alex Horby; Olesen, M; Larsen, Anders Peter; Knop, F K; Wang, Fan; Nielsen, J B; Andersen, M N; Humphreys, David T; Preiss, Thomas

Description

The two-pore domain potassium channel, K2P3.1 (TASK-1) modulates background conductance in isolated human atrial cardiomyocytes and has been proposed as a potential drug target for atrial fibrillation (AF). TASK-1 knockout mice have a predominantly ventricular phenotype however, and effects of TASK-1 inactivation on atrial structure and function have yet to be demonstrated in vivo. The extent to which genetic variation in KCNK3, that encodes TASK-1, might be a determinant of susceptibility to...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/68902
Source: Journal of Molecular and Cellular Cardiology
DOI: 10.1016/j.yjmcc.2013.12.014

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