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Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria

Haque, Ashraful; Best, Shannon; Unosson, Klara; Amante, Fiona H; de Labastida, Fabian; Anstey, Nicholas; Karupiah, Gunasegaran; Smyth, Mark J; Heath, William R; Engwerda, Christian R

Description

Parasite burden predicts disease severity in malaria and risk of death in cerebral malaria patients. In murine experimental cerebral malaria (ECM), parasite burden and CD8+ T cells promote disease by mechanisms that are not fully understood. We found that the majority of brain-recruited CD8+ T cells expressed granzyme B (GzmB). Furthermore, gzmB-/- mice harbored reduced parasite numbers in the brain as a consequence of enhanced antiparasitic CD4+ T cell responses and were protected from ECM. We...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/68878
Source: Journal of Immunology
DOI: 10.4049/jimmunol.1003955

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