Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria
Haque, Ashraful; Best, Shannon; Unosson, Klara; Amante, Fiona H; de Labastida, Fabian; Anstey, Nicholas; Karupiah, Gunasegaran; Smyth, Mark J; Heath, William R; Engwerda, Christian R
Description
Parasite burden predicts disease severity in malaria and risk of death in cerebral malaria patients. In murine experimental cerebral malaria (ECM), parasite burden and CD8+ T cells promote disease by mechanisms that are not fully understood. We found that the majority of brain-recruited CD8+ T cells expressed granzyme B (GzmB). Furthermore, gzmB-/- mice harbored reduced parasite numbers in the brain as a consequence of enhanced antiparasitic CD4+ T cell responses and were protected from ECM. We...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/68878 |
Source: | Journal of Immunology |
DOI: | 10.4049/jimmunol.1003955 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Haque_Granzyme_B_expression_by_CD8+_2011.pdf | 1.2 MB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 20 July 2017/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator