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The Globular Heads of the C1q Receptor Regulate Apoptosis in Human Extravillous Cytotrophoblast-derived Transformed Cells via a Mitochondria-dependent Pathway

Wang, Ying; Guo, Shu-Yu; Gu, Ping-Qing; Yang, Xiao-man; Sun, Ning; Gao, Ling-Juan

Description

Problem: The receptor for the globular head of human C1q (gC1qR) predominantly localizes to the mitochondrial matrix. gC1qR mediates many biological responses, including growth perturbations, morphological abnormalities and the initiation of apoptosis. The purpose of this study was to investigate the relationship between gC1qR expression, mitochondrial dysfunction and the regulation of apoptosis in human extravillous cytotrophoblast (EVCT)-derived transformed cell lines (HTR-8/SVneo and HPT-8)....[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/68715
Source: American Journal of Reproductive Immunology
DOI: 10.1111/aji.12160

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