Nano-osteoimmunology as an important consideration in the design of future implants
Pal, Neha; Quah, Ben; Smith, Paul; Gladkis, Laura; Timmers, Heiko; Li, Rachel
The size of wear particles emanating from a prosthesis at interfaces is critical to the interfacial properties of the joint replacement and responses from the biological environment. Nanoscale particles in particular require investigation. This project aimed to evaluate the osteoimmunological response to nanoscale ultrahigh molecular weight polyethylene (UHMWPE) wear particles in vitro, including dendritic cells (DCs), macrophages, osteoclasts (OCs), cytokine secretion, and co-cultured OCs and...[Show more]
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