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Identification of a novel antigen cross-presenting cell type in spleen

Tan, Jonathan; Quah, Ben; Griffiths, Kristin; Periasamy, Pravin; Hey, Ying Ying; O'Neill, Helen


Antigen-presenting cells (APC), like dendritic cells (DC), are essential for T-cell activation, leading to immunity or tolerance. Multiple DC subsets each play a unique role in the immune response. Here, a novel splenic dendritic-like APC has been characterized in mice that has immune function and cell surface phenotype distinct from other, described DC subsets. These were identified as a cell type continuously produced in spleen long-term cultures (LTC) and have anin vivoequivalent cell type...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Cellular and Molecular Medicine
DOI: 10.1111/j.1582-4934.2010.01089.x
Access Rights: Open Access


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