Dulhunty, Angela; Casarotto, Marco; Beard, Nicole
The ryanodine receptor (RyR) calcium release channel is an essential intracellular ion channel that is central to Ca2+ signaling and contraction in the heart and skeletal muscle. The rapid release of Ca2+ from the internal sarcoplasmic reticulum Ca2+ stores through the RyR during excitation-contraction coupling is facilitated by the unique arrangement of the surface and sarcoplasmic reticulum membrane systems. Debilitating and sometimes fatal skeletal and cardio-myopathies result from changes...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.