The Ryanodine Receptor: A pivotal Ca 2+ Regulatory Protein and Potential Therapeutic Drug Target
The ryanodine receptor (RyR) calcium release channel is an essential intracellular ion channel that is central to Ca2+ signaling and contraction in the heart and skeletal muscle. The rapid release of Ca2+ from the internal sarcoplasmic reticulum Ca2+ stores through the RyR during excitation-contraction coupling is facilitated by the unique arrangement of the surface and sarcoplasmic reticulum membrane systems. Debilitating and sometimes fatal skeletal and cardio-myopathies result from changes...[Show more]
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