The Ryanodine Receptor: A pivotal Ca 2+ Regulatory Protein and Potential Therapeutic Drug Target
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Dulhunty, Angela; Casarotto, Marco; Beard, Nicole
Description
The ryanodine receptor (RyR) calcium release channel is an essential intracellular ion channel that is central to Ca2+ signaling and contraction in the heart and skeletal muscle. The rapid release of Ca2+ from the internal sarcoplasmic reticulum Ca2+ stores through the RyR during excitation-contraction coupling is facilitated by the unique arrangement of the surface and sarcoplasmic reticulum membrane systems. Debilitating and sometimes fatal skeletal and cardio-myopathies result from changes...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/68604 |
Source: | Current Drug Targets |
DOI: | 10.2174/138945011795378595 |
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File | Description | Size | Format | Image |
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01_Dulhunty_The_Ryanodine_Receptor:_A_2011.pdf | 512.94 kB | Adobe PDF | Request a copy |
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