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Chromatin-Associated Protein Kinase C-θ Regulates an Inducible Gene Expression Program and MicroRNAs in Human T Lymphocytes

Sutcliffe, Elissa; Bunting, Karen L; He, Yiqing; Li, Jasmine; Phetsouphanh, Chansavath; Seddiki, Nabila; Zafar, Anjum; Hindmarsh, Elizabeth; Kelleher, Anthony D; McInnes, Russell; Taya, Toshiki; Milburn, Peter J; Rao, Sudha; Parish, Christopher

Description

Studies in yeast demonstrate that signaling kinases have a surprisingly active role in the nucleus, where they tether to chromatin and modulate gene expression programs. Despite these seminal studies, the nuclear mechanism of how signaling kinases control transcription of mammalian genes is in its infancy. Here, we provide evidence for a hitherto unknown function of protein kinase C-theta (PKC-θ), which physically associates with the regulatory regions of inducible immune response genes in...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/68483
Source: Molecular Cell
DOI: 10.1016/j.molcel.2011.02.030

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