Chromatin-Associated Protein Kinase C-θ Regulates an Inducible Gene Expression Program and MicroRNAs in Human T Lymphocytes
Sutcliffe, Elissa; Bunting, Karen; He, Yiqing; Li, Jasmine; Phetsouphanh, Chansavath; Seddiki, Nabila; Zafar, Anjum; Hindmarsh, Elizabeth; Kelleher, Anthony D; McInnes, Russell; Taya, Toshiki; Milburn, Peter J; Rao, Sudha; Parish, Christopher
Studies in yeast demonstrate that signaling kinases have a surprisingly active role in the nucleus, where they tether to chromatin and modulate gene expression programs. Despite these seminal studies, the nuclear mechanism of how signaling kinases control transcription of mammalian genes is in its infancy. Here, we provide evidence for a hitherto unknown function of protein kinase C-theta (PKC-θ), which physically associates with the regulatory regions of inducible immune response genes in...[Show more]
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