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A Total Synthesis of Galanthamine Involving De Novo Construction of the Aromatic C-Ring

Nugent, Jeremy; Matousova, Eliska; Banwell, Martin

Description

The tetracyclic alkaloid galanthamine is used clinically in a number of countries for the symptomatic treatment of mild to moderate forms of Alzheimer's disease, and this feature coupled with its novel molecular architecture has prompted an extensive focus on its synthesis. The present study reports a new and distinct synthesis of galanthamine wherein the AB-ring substructure and associated quaternary carbon centre are constructed by using a palladium-catalyzed intramolecular Alder-ene...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/68400
Source: European Journal of Organic Chemistry
DOI: 10.1002/ejoc.201500365

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