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Using cognitive decline in novel trial designs for primary prevention and early disease-modifying therapy trials of Alzheimer's disease

Darby, David; Brodtmann, Amy; Woodward, Michael; Budge, Marc; Maruff, Paul


Background: Ideally putative disease-modifying therapies for Alzheimer's disease (AD) should be tested in patients who have minimal morbidity. Current barriers to such trials in early disease include the lack of disease-specific early biomarkers, insensitivity of quantitative cognitive outcome measures, and expensive trial designs requiring large sample sizes and long duration. This paper describes principles and progress towards a novel trial design that overcomes these problems, utilizing...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: International Psychogeriatrics
DOI: 10.1017/S1041610211000354


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