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Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss

Ritchie, K; Jaussent, Isabelle; Portet, Forence; Courtet, Philippe; Malafosse, Alain; Maller, Jerome J.; Meslin, Chantal; Bonafe, Alain; Le Bars, Emmanuelle; Menjot de Champfleur, Nicolas; Artero, Sylvaine; Ancelin, Marie-Laure

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Childhood adversity has been observed to engender structural changes in the hippocampus and corpus callosum associated with increased risk for depression in childhood and early adulthood. This study investigated this association in the elderly. Corpus callosum area and hippocampal volume were measured from structural MRI in 427 community dwelling elderly. Information on childhood adversity was obtained in the course of a clinical examination using a questionnaire covering multiple aspects of...[Show more]

dc.contributor.authorRitchie, K
dc.contributor.authorJaussent, Isabelle
dc.contributor.authorPortet, Forence
dc.contributor.authorCourtet, Philippe
dc.contributor.authorMalafosse, Alain
dc.contributor.authorMaller, Jerome J.
dc.contributor.authorMeslin, Chantal
dc.contributor.authorBonafe, Alain
dc.contributor.authorLe Bars, Emmanuelle
dc.contributor.authorMenjot de Champfleur, Nicolas
dc.contributor.authorArtero, Sylvaine
dc.contributor.authorAncelin, Marie-Laure
dc.date.accessioned2015-12-10T23:30:55Z
dc.identifier.issn0165-0327
dc.identifier.urihttp://hdl.handle.net/1885/68384
dc.description.abstractChildhood adversity has been observed to engender structural changes in the hippocampus and corpus callosum associated with increased risk for depression in childhood and early adulthood. This study investigated this association in the elderly. Corpus callosum area and hippocampal volume were measured from structural MRI in 427 community dwelling elderly. Information on childhood adversity was obtained in the course of a clinical examination using a questionnaire covering multiple aspects of abuse. Multivariate analyses found a significant increase in corpus callosum area and hippocampal volume in subjects exposed to mental disorder in parents and poverty, respectively. No association was found with childhood sexual and physical abuse.
dc.publisherElsevier
dc.sourceJournal of Affective Disorders
dc.subjectKeywords: aged; article; brain size; child psychiatry; childhood adversity; corpus callosum; depression; disease association; DSM-IV; female; hippocampal loss; hippocampus; human; interview; major clinical study; major depression; male; neuroimaging; nuclear magnet Child abuse; Corpus callosum; Depression; Elderly; Hippocampus; Magnetic resonance imaging
dc.titleDepression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume141
dc.date.issued2012
local.identifier.absfor111714 - Mental Health
local.identifier.ariespublicationf5625xPUB1697
local.type.statusPublished Version
local.contributor.affiliationRitchie, K, French National Institute of Medical Research (INSERM)
local.contributor.affiliationJaussent, Isabelle, French National Institute of Medical Research (INSERM)
local.contributor.affiliationPortet, Forence, French National Institute of Medical Research (INSERM)
local.contributor.affiliationCourtet, Philippe, Institut National de la Sante et de la Recherche Medicale (INSERM)
local.contributor.affiliationMalafosse, Alain, Institut National de la Sante et de la Recherche Medicale (INSERM),
local.contributor.affiliationMaller, Jerome J., The Alfred & Monash University
local.contributor.affiliationMeslin, Chantal, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBonafe, Alain, University of Montpellier 1
local.contributor.affiliationLe Bars, Emmanuelle, University of Montpellier 1
local.contributor.affiliationMenjot de Champfleur, Nicolas, University of Montpellier 1
local.contributor.affiliationArtero, Sylvaine, Institut National de la Sante et de la Recherche Medicale (INSERM),
local.contributor.affiliationAncelin, Marie-Laure, French National Institute of Medical Research (INSERM)
local.description.embargo2037-12-31
local.bibliographicCitation.issue2-3
local.bibliographicCitation.startpage294
local.bibliographicCitation.lastpage299
local.identifier.doi10.1016/j.jad.2012.03.035
dc.date.updated2016-02-24T08:49:59Z
local.identifier.scopusID2-s2.0-84867574900
local.identifier.thomsonID000311237700023
CollectionsANU Research Publications

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