Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss
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Ritchie, K; Jaussent, Isabelle; Portet, Forence; Courtet, Philippe; Malafosse, Alain; Maller, Jerome J.; Meslin, Chantal; Bonafe, Alain; Le Bars, Emmanuelle; Menjot de Champfleur, Nicolas; Artero, Sylvaine; Ancelin, Marie-Laure
Description
Childhood adversity has been observed to engender structural changes in the hippocampus and corpus callosum associated with increased risk for depression in childhood and early adulthood. This study investigated this association in the elderly. Corpus callosum area and hippocampal volume were measured from structural MRI in 427 community dwelling elderly. Information on childhood adversity was obtained in the course of a clinical examination using a questionnaire covering multiple aspects of...[Show more]
dc.contributor.author | Ritchie, K | |
---|---|---|
dc.contributor.author | Jaussent, Isabelle | |
dc.contributor.author | Portet, Forence | |
dc.contributor.author | Courtet, Philippe | |
dc.contributor.author | Malafosse, Alain | |
dc.contributor.author | Maller, Jerome J. | |
dc.contributor.author | Meslin, Chantal | |
dc.contributor.author | Bonafe, Alain | |
dc.contributor.author | Le Bars, Emmanuelle | |
dc.contributor.author | Menjot de Champfleur, Nicolas | |
dc.contributor.author | Artero, Sylvaine | |
dc.contributor.author | Ancelin, Marie-Laure | |
dc.date.accessioned | 2015-12-10T23:30:55Z | |
dc.identifier.issn | 0165-0327 | |
dc.identifier.uri | http://hdl.handle.net/1885/68384 | |
dc.description.abstract | Childhood adversity has been observed to engender structural changes in the hippocampus and corpus callosum associated with increased risk for depression in childhood and early adulthood. This study investigated this association in the elderly. Corpus callosum area and hippocampal volume were measured from structural MRI in 427 community dwelling elderly. Information on childhood adversity was obtained in the course of a clinical examination using a questionnaire covering multiple aspects of abuse. Multivariate analyses found a significant increase in corpus callosum area and hippocampal volume in subjects exposed to mental disorder in parents and poverty, respectively. No association was found with childhood sexual and physical abuse. | |
dc.publisher | Elsevier | |
dc.source | Journal of Affective Disorders | |
dc.subject | Keywords: aged; article; brain size; child psychiatry; childhood adversity; corpus callosum; depression; disease association; DSM-IV; female; hippocampal loss; hippocampus; human; interview; major clinical study; major depression; male; neuroimaging; nuclear magnet Child abuse; Corpus callosum; Depression; Elderly; Hippocampus; Magnetic resonance imaging | |
dc.title | Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 141 | |
dc.date.issued | 2012 | |
local.identifier.absfor | 111714 - Mental Health | |
local.identifier.ariespublication | f5625xPUB1697 | |
local.type.status | Published Version | |
local.contributor.affiliation | Ritchie, K, French National Institute of Medical Research (INSERM) | |
local.contributor.affiliation | Jaussent, Isabelle, French National Institute of Medical Research (INSERM) | |
local.contributor.affiliation | Portet, Forence, French National Institute of Medical Research (INSERM) | |
local.contributor.affiliation | Courtet, Philippe, Institut National de la Sante et de la Recherche Medicale (INSERM) | |
local.contributor.affiliation | Malafosse, Alain, Institut National de la Sante et de la Recherche Medicale (INSERM), | |
local.contributor.affiliation | Maller, Jerome J., The Alfred & Monash University | |
local.contributor.affiliation | Meslin, Chantal, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Bonafe, Alain, University of Montpellier 1 | |
local.contributor.affiliation | Le Bars, Emmanuelle, University of Montpellier 1 | |
local.contributor.affiliation | Menjot de Champfleur, Nicolas, University of Montpellier 1 | |
local.contributor.affiliation | Artero, Sylvaine, Institut National de la Sante et de la Recherche Medicale (INSERM), | |
local.contributor.affiliation | Ancelin, Marie-Laure, French National Institute of Medical Research (INSERM) | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 2-3 | |
local.bibliographicCitation.startpage | 294 | |
local.bibliographicCitation.lastpage | 299 | |
local.identifier.doi | 10.1016/j.jad.2012.03.035 | |
dc.date.updated | 2016-02-24T08:49:59Z | |
local.identifier.scopusID | 2-s2.0-84867574900 | |
local.identifier.thomsonID | 000311237700023 | |
Collections | ANU Research Publications |
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