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Delayed control of herpes simplex virus infection and impaired CD4+ T-cell migration to the skin in mouse models of DOCK8 deficiency

Flesch, Inge; Randall, Katrina; Hollett (previously Noel), Natasha; Law, Hsei-Di; Miosge, Lisa; Sontani, Yovina; Goodnow, Christopher; Tscharke, David

Description

DOCK8 deficiency in humans and mice leads to multiple defects in immune cell numbers and function. Patients with this immunodeficiency have a high morbidity and mortality, and are distinguished by chronic cutaneous viral infections, including those caused by herpes simplex virus (HSV). The underlying mechanism of the specific susceptibility to these chronic cutaneous viral infections is currently unknown, largely because the effect of DOCK8 deficiency has not been studied in suitable models. A...[Show more]

dc.contributor.authorFlesch, Inge
dc.contributor.authorRandall, Katrina
dc.contributor.authorHollett (previously Noel), Natasha
dc.contributor.authorLaw, Hsei-Di
dc.contributor.authorMiosge, Lisa
dc.contributor.authorSontani, Yovina
dc.contributor.authorGoodnow, Christopher
dc.contributor.authorTscharke, David
dc.date.accessioned2015-12-10T23:30:39Z
dc.identifier.issn0818-9641
dc.identifier.urihttp://hdl.handle.net/1885/68278
dc.description.abstractDOCK8 deficiency in humans and mice leads to multiple defects in immune cell numbers and function. Patients with this immunodeficiency have a high morbidity and mortality, and are distinguished by chronic cutaneous viral infections, including those caused by herpes simplex virus (HSV). The underlying mechanism of the specific susceptibility to these chronic cutaneous viral infections is currently unknown, largely because the effect of DOCK8 deficiency has not been studied in suitable models. A better understanding of these mechanisms is required to underpin the development of more specific therapies. Here we show that DOCK8-deficient mice have poor control of primary cutaneous herpes simplex lesions and this is associated with increased virus loads. Furthermore, DOCK8-deficient mice showed a lack of CD4+ T-cell infiltration into HSV-infected skin.Immunology and Cell Biology advance online publication, 17 March 2015; doi:10.1038/icb.2015.32.
dc.publisherBlackwell Publishing Ltd
dc.sourceImmunology and Cell Biology
dc.titleDelayed control of herpes simplex virus infection and impaired CD4+ T-cell migration to the skin in mouse models of DOCK8 deficiency
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume93
dc.date.issued2015
local.identifier.absfor110700 - IMMUNOLOGY
local.identifier.ariespublicationa383154xPUB1667
local.type.statusPublished Version
local.contributor.affiliationFlesch, Inge, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationRandall, Katrina, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHollett (previously Noel), Natasha, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLaw, Hsei-Di, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMiosge, Lisa, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSontani, Yovina, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGoodnow, Christopher, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTscharke, David, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue2015
local.bibliographicCitation.startpage517
local.bibliographicCitation.lastpage521
local.identifier.doi10.1038/icb.2015.32
dc.date.updated2015-12-10T11:08:41Z
local.identifier.scopusID2-s2.0-84925115712
CollectionsANU Research Publications

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