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Delayed control of herpes simplex virus infection and impaired CD4+ T-cell migration to the skin in mouse models of DOCK8 deficiency

Flesch, Inge; Randall, Katrina; Hollett (previously Noel), Natasha; Law, Hsei-Di; Miosge, Lisa; Sontani, Yovina; Goodnow, Christopher; Tscharke, David


DOCK8 deficiency in humans and mice leads to multiple defects in immune cell numbers and function. Patients with this immunodeficiency have a high morbidity and mortality, and are distinguished by chronic cutaneous viral infections, including those caused by herpes simplex virus (HSV). The underlying mechanism of the specific susceptibility to these chronic cutaneous viral infections is currently unknown, largely because the effect of DOCK8 deficiency has not been studied in suitable models. A...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1038/icb.2015.32


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