Season of birth and childhood food allergy in Australia
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Mullins, Raymond; Clark, Sunday; Katelaris, Constance; Smith, Victoria; Solley, Graham; Camargo, Carlos A
Description
Background: Recent studies suggest a possible role for low ultraviolet radiation exposure and low vitamin D status as a risk factor for food allergy. We hypothesized that children born in autumn/winter months (less sun exposure) might have higher food allergy rates than those born in spring/summer. Methods: We compared IgE-mediated food allergy rates by season of birth in 835 children aged 0-4yr assessed 1995-2009 in a specialist referral clinic, using population births as controls. To address...[Show more]
dc.contributor.author | Mullins, Raymond | |
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dc.contributor.author | Clark, Sunday | |
dc.contributor.author | Katelaris, Constance | |
dc.contributor.author | Smith, Victoria | |
dc.contributor.author | Solley, Graham | |
dc.contributor.author | Camargo, Carlos A | |
dc.date.accessioned | 2015-12-10T23:27:22Z | |
dc.identifier.issn | 0905-6157 | |
dc.identifier.uri | http://hdl.handle.net/1885/68192 | |
dc.description.abstract | Background: Recent studies suggest a possible role for low ultraviolet radiation exposure and low vitamin D status as a risk factor for food allergy. We hypothesized that children born in autumn/winter months (less sun exposure) might have higher food allergy rates than those born in spring/summer. Methods: We compared IgE-mediated food allergy rates by season of birth in 835 children aged 0-4yr assessed 1995-2009 in a specialist referral clinic, using population births as controls. To address potential concerns about generalizability, we also examined national prescriptions for adrenaline autoinjectors (2007) and infant hypoallergenic formula (2006-2007). Results: Although live births in the general ACT population showed no seasonal pattern (50% autumn/winter vs. 50% spring/summer), autumn/winter births were more common than spring/summer births among food allergy patients (57% vs. 43%; p<0.001). The same seasonal pattern was observed with peanut (60% vs. 40%; p<0.001) and egg (58% vs. 42%; p=0.003). Regional UVR intensity was correlated with relative rate of overall food allergy (β, -1.83; p=0.05) and peanut allergy (β, -3.27; p=0.01). National data showed that autumn/winter births also were more common among children prescribed EpiPens (54% vs. 46%; p<0.001) and infant hypoallergenic formula (54% vs. 46%; p<0.001). Conclusions: The significantly higher rates of food allergy in children born autumn/winter (compared to spring/summer), the relationship between relative food allergy rates and monthly UVR, combined with national adrenaline autoinjector and infant hypoallergenic formula prescription data, suggest that ultraviolet light exposure/vitamin D status may be one of many potential factors contributing to childhood food allergy pathogenesis. | |
dc.publisher | Blackwell Publishing Ltd | |
dc.source | Pediatric Allergy and Immunology | |
dc.subject | Keywords: adrenalin; article; artificial milk; Australia; autumn; birth; child; childhood disease; controlled study; disease association; egg allergy; female; food allergy; human; infant; live birth; major clinical study; male; milk allergy; nut allergy; peanut all Birth season; Epidemiology; Food allergy; Sunlight; Vitamin D | |
dc.title | Season of birth and childhood food allergy in Australia | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 22 | |
dc.date.issued | 2011 | |
local.identifier.absfor | 110701 - Allergy | |
local.identifier.ariespublication | f2965xPUB1644 | |
local.type.status | Published Version | |
local.contributor.affiliation | Mullins, Raymond, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Clark, Sunday, University of Pittsburgh | |
local.contributor.affiliation | Katelaris, Constance, University of Western Sydney | |
local.contributor.affiliation | Smith, Victoria, Rose Cottage Medical Centre | |
local.contributor.affiliation | Solley, Graham, Watkins Medical Centre | |
local.contributor.affiliation | Camargo, Carlos A, Massachusetts General Hospital | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 6 | |
local.bibliographicCitation.startpage | 583 | |
local.bibliographicCitation.lastpage | 589 | |
local.identifier.doi | 10.1111/j.1399-3038.2011.01151.x | |
local.identifier.absseo | 970111 - Expanding Knowledge in the Medical and Health Sciences | |
dc.date.updated | 2016-02-24T08:15:59Z | |
local.identifier.scopusID | 2-s2.0-79955779417 | |
Collections | ANU Research Publications |
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