Suicidal Behavior Is Associated with Reduced Corpus Callosum Area
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Cyprien, Fabienne; Courtet, Philippe; Malafosse, Alain; Maller, Jerome J.; Meslin, Chantal; Bonafe, Alain; Le Bars, Emmanuelle; Menjot de Champfleur, Nicolas; Ritchie, K; Artero, Sylvaine
Description
Background: Corpus callosum (CC) size has been associated with cognitive and emotional deficits in a range of neuropsychiatric and mood disorders. As such deficits are also found in suicidal behavior, we investigated specifically the association between CC atrophy and suicidal behavior. Methods: We studied 435 right-handed individuals without dementia from a cohort of community-dwelling persons aged 65 years and over (the ESPRIT study). They were divided in three groups: suicide attempters (n =...[Show more]
dc.contributor.author | Cyprien, Fabienne | |
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dc.contributor.author | Courtet, Philippe | |
dc.contributor.author | Malafosse, Alain | |
dc.contributor.author | Maller, Jerome J. | |
dc.contributor.author | Meslin, Chantal | |
dc.contributor.author | Bonafe, Alain | |
dc.contributor.author | Le Bars, Emmanuelle | |
dc.contributor.author | Menjot de Champfleur, Nicolas | |
dc.contributor.author | Ritchie, K | |
dc.contributor.author | Artero, Sylvaine | |
dc.date.accessioned | 2015-12-10T23:27:07Z | |
dc.identifier.issn | 0006-3223 | |
dc.identifier.uri | http://hdl.handle.net/1885/68079 | |
dc.description.abstract | Background: Corpus callosum (CC) size has been associated with cognitive and emotional deficits in a range of neuropsychiatric and mood disorders. As such deficits are also found in suicidal behavior, we investigated specifically the association between CC atrophy and suicidal behavior. Methods: We studied 435 right-handed individuals without dementia from a cohort of community-dwelling persons aged 65 years and over (the ESPRIT study). They were divided in three groups: suicide attempters (n = 21), affective control subjects (AC) (n = 180) without history of suicide attempt but with a history of depression, and healthy control subjects (HC) (n = 234). T1-weighted magnetic resonance images were traced to measure the midsagittal areas of the anterior, mid, and posterior CC. Multivariate analysis of covariance was used to compare CC areas in the three groups. Results: Multivariate analyses adjusted for age, gender, childhood trauma, head trauma, and total brain volume showed that the area of the posterior third of CC was significantly smaller in suicide attempters than in AC (p =.020) and HC (p =.010) individuals. No significant differences were found between AC and HC. No differences were found for the anterior and mid thirds of the CC. Conclusions: Our findings emphasize a reduced size of the posterior third of the CC in subjects with a history of suicide, suggesting a diminished interhemispheric connectivity and a possible role of CC in the pathophysiology of suicidal behavior. Further studies are needed to strengthen these results and clarify the underlying cellular changes leading to these morphometric differences. | |
dc.publisher | Elsevier | |
dc.source | Biological Psychiatry | |
dc.subject | Keywords: aged; article; brain atrophy; brain size; controlled study; corpus callosum; depression; female; hemisphere; human; major clinical study; male; nuclear magnetic resonance imaging; pathophysiology; priority journal; suicidal behavior; suicide attempt; Aged Corpus callosum; magnetic resonance imaging; suicidal behavior | |
dc.title | Suicidal Behavior Is Associated with Reduced Corpus Callosum Area | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 70 | |
dc.date.issued | 2011 | |
local.identifier.absfor | 170101 - Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) | |
local.identifier.absfor | 111714 - Mental Health | |
local.identifier.ariespublication | f2965xPUB1612 | |
local.type.status | Published Version | |
local.contributor.affiliation | Cyprien, Fabienne, Institut National de la Sante et de la Recherche Medicale (INSERM) | |
local.contributor.affiliation | Courtet, Philippe, Institut National de la Sante et de la Recherche Medicale (INSERM) | |
local.contributor.affiliation | Malafosse, Alain, Institut National de la Sante et de la Recherche Medicale (INSERM), | |
local.contributor.affiliation | Maller, Jerome J., The Alfred & Monash University | |
local.contributor.affiliation | Meslin, Chantal, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Bonafe, Alain, University of Montpellier 1 | |
local.contributor.affiliation | Le Bars, Emmanuelle, University of Montpellier 1 | |
local.contributor.affiliation | Menjot de Champfleur, Nicolas, University of Montpellier 1 | |
local.contributor.affiliation | Ritchie, K, French National Institute of Medical Research (INSERM) | |
local.contributor.affiliation | Artero, Sylvaine, Institut National de la Sante et de la Recherche Medicale (INSERM), | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 4 | |
local.bibliographicCitation.startpage | 320 | |
local.bibliographicCitation.lastpage | 326 | |
local.identifier.doi | 10.1016/j.biopsych.2011.02.035 | |
local.identifier.absseo | 970111 - Expanding Knowledge in the Medical and Health Sciences | |
local.identifier.absseo | 920410 - Mental Health | |
dc.date.updated | 2016-02-24T08:15:40Z | |
local.identifier.scopusID | 2-s2.0-79960456262 | |
local.identifier.thomsonID | 000293080400010 | |
Collections | ANU Research Publications |
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