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From cis-regulatory elements to complex RNPs and back

Gebauer, F; Preiss, Thomas; Hentze, Matthias


Messenger RNAs (mRNAs), the templates for translation, have evolved to harbor abundant cis-acting sequences that affect their posttranscriptional fates. These elements are frequently located in the untranslated regions and serve as binding sites for trans-acting factors, RNA-binding proteins, and/or small non-coding RNAs. This article provides a systematic synopsis of cis-acting elements, trans-acting factors, and the mechanisms by which they affect translation. It also highlights recent...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Cold Spring Harbor Perspectives in Biology
DOI: 10.1101/cshperspect.a012245


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