Skip navigation
Skip navigation
The system will be down for maintenance between 8:00 and 8:15am on Thursday 13, December 2018

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

Castello, Alfredo; Fischer, Bernd; Eichelbaum, Katrin; Horos, Rastislav; Beckmann, Benedikt; Strein, Claudia; Davey, Norman E; Humphreys, David T; Preiss, Thomas; Steinmetz, Lars M; Krijgsveld, Jeroen

Description

RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two complementary protocols for covalent UV crosslinking of RBPs to RNA, we describe a systematic, unbiased, and comprehensive approach, termed "interactome capture," to define the mRNA interactome of proliferating human HeLa cells. We identify 860 proteins that qualify as RBPs by biochemical and statistical criteria, adding more than 300 RBPs to those previously known and shedding light on RBPs in disease,...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/67943
Source: Cell
DOI: 10.1016/j.cell.2012.04.031

Download

File Description SizeFormat Image
01_Castello_Insights_into_RNA_Biology_from_2012.pdf1.42 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  27 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator