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Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder

Hornig, Mady; Briese, Thomas; Licinio, Julio; Khabbaz, Rima F.; Altshuler, Lori L; Potkin, Steven G; Schwemmle, Martin; Siemetzki, U; Mintz, J; Honkavuori, K; Kraemer, H C


In 1983, reports of antibodies in subjects with major depressive disorder (MDD) to an as-yet uncharacterized infectious agent associated with meningoencephalitis in horses and sheep led to molecular cloning of the genome of a novel, negative-stranded neurotropic virus, Borna disease virus (BDV). This advance has enabled the development of new diagnostic assays, including in situ hybridization, PCR and serology based on recombinant proteins. Since these assays were first implemented in 1990,...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Molecular Psychiatry
DOI: 10.1038/mp.2011.179


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