Hornig, Mady; Briese, Thomas; Licinio, Julio; Khabbaz, Rima F.; Altshuler, Lori L; Potkin, Steven G; Schwemmle, Martin; Siemetzki, U; Mintz, J; Honkavuori, K; Kraemer, H C
In 1983, reports of antibodies in subjects with major depressive disorder (MDD) to an as-yet uncharacterized infectious agent associated with meningoencephalitis in horses and sheep led to molecular cloning of the genome of a novel, negative-stranded neurotropic virus, Borna disease virus (BDV). This advance has enabled the development of new diagnostic assays, including in situ hybridization, PCR and serology based on recombinant proteins. Since these assays were first implemented in 1990,...[Show more]
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