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Morphological, functional and gene expression analysis of the hyperoxic mouse retina

Natoli, Riccardo; Valter (Valter-Kocsi), Krisztina; Chrysostomou, Vicki; Stone, Jonathan; Provis, Jan


This study examined the impact of prolonged (up to 35 day) exposure to hyperoxia on the morphology and function of the retina, in the C57BL/6J mouse, as a basis for interpretation of gene expression changes. Mice of the C57BL/6J strain were raised from birth in dim cyclic illumination (12 h 5 lux, 12 h dark). Adult animals (90-110 days) were exposed to continuous hyperoxia (75% oxygen) for up to 35 d. Retinas were examined after 0 d (controls), 3 d, 7 d, 14 d and 35 d. Spatial and temporal...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Experimental Eye Research
DOI: 10.1016/j.exer.2010.12.013


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