Congenital leptin deficiency: Diagnosis and effects of leptin replacement therapy
To describe our 10-year experience in treating leptin-deficient humans. Three adults and one boy presented with childhood-onset morbid obesity, hypogonadism and family history of obesity and early death. Serum leptin was inappropriately low. A recessive C105T leptin gene mutation was identified. Metabolic and endocrine assessments were conducted, before and while on and off leptin. The adults' body mass index decreased from 51.2 ± 2.5 to 29.5 ± 2.8 kg/m2. Serum lipids normalized, insulin...[Show more]
|Collections||ANU Research Publications|
|Source:||Arquivos Brasileiros de Endocrinologia e Metabologia|
|01_Da Paz Filho_Congenital_leptin_deficiency:_2010.pdf||1.34 MB||Adobe PDF||Request a copy|
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