Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu
The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels and enhances the process of virion budding and release. Mutagenesis studies have shown that the N-terminal transmembrane domain primarily controls both of these activities. Here we report that the Vpu ion channel is inhibited by the amiloride derivatives 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride but not by amiloride itself, nor by amantadine. Hexamethyleneamiloride also inhibits budding...[Show more]
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|Source:||European Biophysics Journal|
|01_Ewart_Amiloride_derivatives_block_2002.pdf||230.26 kB||Adobe PDF||Request a copy|
|02_Ewart_Amiloride_derivatives_block_2002.pdf||230.26 kB||Adobe PDF||Request a copy|
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