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Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu

Ewart, Gary; Mills, Kerry; Cox, Graeme; Gage, Peter


The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels and enhances the process of virion budding and release. Mutagenesis studies have shown that the N-terminal transmembrane domain primarily controls both of these activities. Here we report that the Vpu ion channel is inhibited by the amiloride derivatives 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride but not by amiloride itself, nor by amantadine. Hexamethyleneamiloride also inhibits budding...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: European Biophysics Journal
DOI: 10.1007/s002490100177


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