Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu
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Ewart, Gary; Mills, Kerry; Cox, Graeme; Gage, Peter
Description
The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels and enhances the process of virion budding and release. Mutagenesis studies have shown that the N-terminal transmembrane domain primarily controls both of these activities. Here we report that the Vpu ion channel is inhibited by the amiloride derivatives 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride but not by amiloride itself, nor by amantadine. Hexamethyleneamiloride also inhibits budding...[Show more]
Collections | ANU Research Publications |
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Date published: | 2002 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/67726 |
Source: | European Biophysics Journal |
DOI: | 10.1007/s002490100177 |
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02_Ewart_Amiloride_derivatives_block_2002.pdf | 230.26 kB | Adobe PDF | Request a copy |
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