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Histidine-rich glycoprotein: The Swiss Army knife of mammalian plasma

Poon, Ivan; Patel, Kruti K; Simon Davis (S Davis), David; Hulett, Mark; Parish, Christopher


Histidine-rich glycoprotein (HRG), also known as histidine-proline-rich glycoprotein, is an abundant and well-characterized protein of vertebrate plasma. HRG has a multidomain structure that allows the molecule to interact with many ligands, including heparin, phospholipids, plasminogen, fibrinogen, immunoglobulin G, C1q, heme, and Zn2+. The ability of HRG to interact with various ligands simultaneously has suggested that HRG can function as an adaptor molecule and regulate numerous important...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Blood
DOI: 10.1182/blood-2010-09-303842


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