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Snake venoms are integrated systems, but abundant venom proteins evolve more rapidly

Aird, Steven D.; Aggarwal, Shikha; Villar-Briones, Alejandro; Tin, Mandy M.Y.; Terada, Kouki; Mikheyev, Alexander

Description

Background: While many studies have shown that extracellular proteins evolve rapidly, how selection acts on them remains poorly understood. We used snake venoms to understand the interaction between ecology, expression level, and evolutionary rate in secreted protein systems. Venomous snakes employ well-integrated systems of proteins and organic constituents to immobilize prey. Venoms are generally optimized to subdue preferred prey more effectively than non-prey, and many venom protein...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/67641
Source: BMC Genomics
DOI: 10.1186/s12864-015-1832-6

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