Altin, John; Tian, Lei; Liston, Adrian; Bertram, Edward; Goodnow, Christopher; Cook, Matthew
Background: Allergy, the most common disease of immune dysregulation, has a substantial genetic component that is poorly understood. Although complete disruption of T-cell receptor (TCR) signaling causes profound immunodeficiency, little is known about the consequences of inherited genetic variants that cause partial quantitative decreases in particular TCR-signaling pathways, despite their potential to dysregulate immune responses and cause immunopathology. Objective: We sought to elucidate...[Show more]
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