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Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T H 2 effector cells to cause allergy

Altin, John; Tian, Lei; Liston, Adrian; Bertram, Edward; Goodnow, Christopher; Cook, Matthew

Description

Background: Allergy, the most common disease of immune dysregulation, has a substantial genetic component that is poorly understood. Although complete disruption of T-cell receptor (TCR) signaling causes profound immunodeficiency, little is known about the consequences of inherited genetic variants that cause partial quantitative decreases in particular TCR-signaling pathways, despite their potential to dysregulate immune responses and cause immunopathology. Objective: We sought to elucidate...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/67624
Source: Journal of Allergy and Clinical Immunology
DOI: 10.1016/j.jaci.2010.12.1081

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