Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T H 2 effector cells to cause allergy
Background: Allergy, the most common disease of immune dysregulation, has a substantial genetic component that is poorly understood. Although complete disruption of T-cell receptor (TCR) signaling causes profound immunodeficiency, little is known about the consequences of inherited genetic variants that cause partial quantitative decreases in particular TCR-signaling pathways, despite their potential to dysregulate immune responses and cause immunopathology. Objective: We sought to elucidate...[Show more]
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|Source:||Journal of Allergy and Clinical Immunology|
|01_Altin_Decreased_T-cell_receptor_2011.pdf||1.54 MB||Adobe PDF||Request a copy|
|02_Altin_Decreased_T-cell_receptor_2011.pdf||1.71 MB||Adobe PDF||Request a copy|
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