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Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii

Ramakrishnan, Srinivasan; Docampo, Melissa D; MacRae, James I; Pujol, Francois M; Brooks, Carrie F; van Dooren, Giel; Hiltunen, J Kalervo; Kastaniotis, Alexander J; McConville, Malcolm J; Striepen, Boris

Description

Apicomplexan parasites are responsible for high impact human diseases such as malaria, toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent on both de novo lipid biosynthesis as well as the uptake of host lipids for biogenesis of parasite membranes. Genome annotations and biochemical studies indicate that apicomplexan parasites can synthesize fatty acids via a number of different biosynthetic pathways that are differentially compartmentalized. However, the...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/67521
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M111.310144

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