Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii
Ramakrishnan, Srinivasan; Docampo, Melissa D; MacRae, James I; Pujol, Francois M; Brooks, Carrie F; van Dooren, Giel; Hiltunen, J Kalervo; Kastaniotis, Alexander J; McConville, Malcolm J; Striepen, Boris
Apicomplexan parasites are responsible for high impact human diseases such as malaria, toxoplasmosis, and cryptosporidiosis. These obligate intracellular pathogens are dependent on both de novo lipid biosynthesis as well as the uptake of host lipids for biogenesis of parasite membranes. Genome annotations and biochemical studies indicate that apicomplexan parasites can synthesize fatty acids via a number of different biosynthetic pathways that are differentially compartmentalized. However, the...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Biological Chemistry|
|01_Ramakrishnan_Apicoplast_and_endoplasmic_2012.pdf||4.7 MB||Adobe PDF|
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