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Energetically Most Likely Substrate and Active-Site Protonation Sites and Pathways in the Catalytic Mechanism of Dihydrofolate Reductase

Cummins, Peter; Gready, Jill


Despite much experimental and computational study, key aspects of the mechanism of reduction of dihydrofolate (DHF) by dihydrofolate reductase (DHFR) remain unresolved, while the secondary DHFR-catalyzed reduction of folate has been little studied. Major

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of the American Chemical Society
DOI: 10.1021/ja0038474


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