Energetically Most Likely Substrate and Active-Site Protonation Sites and Pathways in the Catalytic Mechanism of Dihydrofolate Reductase
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Description
Despite much experimental and computational study, key aspects of the mechanism of reduction of dihydrofolate (DHF) by dihydrofolate reductase (DHFR) remain unresolved, while the secondary DHFR-catalyzed reduction of folate has been little studied. Major
| Collections | ANU Research Publications |
|---|---|
| Date published: | 2001 |
| Type: | Journal article |
| URI: | http://hdl.handle.net/1885/67474 |
| Source: | Journal of the American Chemical Society |
| DOI: | 10.1021/ja0038474 |
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| File | Description | Size | Format | Image |
|---|---|---|---|---|
| 01_Cummins_Energetically_Most_Likely_2001.pdf | 150.12 kB | Adobe PDF | Request a copy |
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