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A novel system for convenient detection of low-affinity receptor-ligand interactions: Chelator-lipid lipsomes engrafted with recombinant CD4 bind to cells expressing MHC class II

Van Broekhoven, Christina; Altin, Joseph


The interactions of cell surface receptors with their ligands, crucial for initiating many immunological responses, are often stabilized by receptor dimerization/oligomerization, and by multimeric interactions between receptors on one cell with their ligands or cognate receptors on the apposing cell. Current techniques for studying receptor-ligand interactions, however, do not always allow receptors to move laterally to enable dimerization/oligomerization, or to interact multimerically with...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1046/j.1440-1711.2001.01010.x


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