A novel system for convenient detection of low-affinity receptor-ligand interactions: Chelator-lipid lipsomes engrafted with recombinant CD4 bind to cells expressing MHC class II
The interactions of cell surface receptors with their ligands, crucial for initiating many immunological responses, are often stabilized by receptor dimerization/oligomerization, and by multimeric interactions between receptors on one cell with their ligands or cognate receptors on the apposing cell. Current techniques for studying receptor-ligand interactions, however, do not always allow receptors to move laterally to enable dimerization/oligomerization, or to interact multimerically with...[Show more]
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