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Size and sulfation are critical for the effect of heparin on APP processing and Aβ production

Cui, Hao; Hung, Amos C; Freeman, Craig; Narkowicz, Christian; Jacobsen, Glenn A.; Small, David H

Description

Alzheimer's disease is associated with abnormal accumulation of Aβ, which is produced from the β-amyloid precursor protein (APP) by the β-site APP-cleaving enzyme (BACE1) and Î-secretase. Our previous studies showed that heparin can decrease APP proce

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/67298
Source: Journal of Neurochemistry
DOI: 10.1111/j.1471-4159.2012.07929.x

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