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Lymphoid and fibroblastic cell lineages from radiosensitive cancer patients: Molecular analysis of DNA double strand break repair by major non-homologous end-joining sub-pathways

McKay, Michael; WITHANA, Nimali; DAVEY, Deborah; Bishop, Danial; Chao, Michael; Sprung, Carl N.


Aims: Radiation therapy (RT) is used in the treatment of approximately half of all cancer patients. Although there have been great improvements in tumor localization and the technical accuracy of RT delivery, some RT patients still have idiosyncratic hypersensitivity to ionizing radiation (IR) in their normal tissues. Although much effort has been expended in the search for assays that could detect radiosensitive individuals prior to treatment and facilitate tailored therapy; a suitable and...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Asia-Pacific Journal of Clinical Oncology
DOI: 10.1111/j.1743-7563.2010.01364.x


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